Whitley H155 GMP Isolator

Got a Question? Request a Callback
Whitley H155 GMP Isolator

Cell optimised isolator providing 1800 litre capacity with dual operator functionality

Rollover Image to Zoom

The Whitley H135 GMP Isolator (GB Patent No. 2593277) is designed to fast track your allogenic approval. Experience unrivalled control and consistency through enhanced contamination reduction, cell behaviour control, and cell growth.

The Whitley Difference:

  1. Contamination Control: ISO3 unidirectional flow - 100X less particles than Grade A. Crucial for safe and effective ATMPs.

  2. Control & Consistency: Ensure consistent processing with customisable atmosphere control (oxygen, carbon dioxide, humidity, and temperature) for in vivo, low oxygen conditions. Improving control of cell behaviour, proliferation, and differentiation.

  3. Enhanced Cell Growth: large incubation and processing capacity with atmosphere control for increased stem cell production and yields.

Designed to ensure batch-batch consistency for:

  • GMP Allogenic Manufacturing
  • Regenerative Medicine
  • iPSC In Vitro Models
  • Tissue Engineering
  • Organoids
  • QC Potency and Efficacy Testing
  • Tumour Microenvironment Assays

Utilising low oxygen control with ISO 3 (100X less particles than Grade A) laminar flow creating an in vivo environment for optimised stem cell growth.

With a compact and closed design, our re-circulating technology enables our isolators to be housed in Grade D cleanrooms. Helping you develop scalable and cost-effective cleanroom alternatives capable of saving $20,000/m in operations.

Process, incubate and refrigerate your oxygen sensitive products in Grade A conditions without the need to expose cells to atmospheric conditions. Avoiding HIF-1 oxygen shock and contamination risks associated with incubator-BSC transfer.


GMP regulations require specialised robust gauntlets to be used in GMP high risk processing applications. Our Cell Optimised Isolators are supplied with an innovative quick change ‘BCS’ gauntlet made of non-shedding material allowing easy and rapid glove changes without loss of containment or atmospheric conditions.


Incubation Module

  1. Relative humidity control up to 80%.
  2. Incubation at 37°C to support cell growth.
  3. CO2 control with 0.1% increments between 0.1% - 15% CO2 in all modules.
  4. O2 control with 0.1% increments between 0.1% - 20% O2 in all modules for hypoxic stem cell culturing.

Cell Processing Module

  1. Capability for two operators to work simultaneously.
  2. Equipment integration for seamless operation within the isolator.
  3. Aseptic transfer system to facilitate use of external equipment inside the isolator.
  4. CO2 control with 0.1% increments between 0.1% - 15% CO2 in all modules.
  5. O2 control with 0.1% increments between 0.1% - 20% O2 in all modules for hypoxic stem cell culturing.

Refrigeration Module

  1. Relative humidity control.
  2. Grade A refrigeration for cell culture reagents at 7°C.
  3. CO2 control with 0.1% increments between 0.1% - 15% CO2 in all modules.
  4. O2 control with 0.1% increments between 0.1% - 20%.

  • Precise oxygen control (between 0.1% and 20%) and CO2 control (between 0.0% and 15%).
  • A large internal working area (2200 x 750 x 620mm) to house larger equipment, eg large scale bioreactors and imaging systems.
  • Precise control of temperature (from ambient to incubation temperature) and humidity.
  • H14 HEPA filter with >99.995% efficiency (MMPS).
  • Large, rapid transfer airlocks - 2 sizes available: 17.5 L (accommodates 16 x T75 flasks) or 43 L (accommodates 64 x T75 flasks).
  • Integrated VHP biodecontamination with isolated chamber sterilisation for continued processing in adjacent modules (glove extenders supplied for complete glove cleaning).
  • Ethernet-enabled for remote access review and control.
  • Whitley Intelligent Monitoring - Environmental and atmospheric sensors measuring and controlling airflow, airspeed, positive pressure, O2, CO2, temperature, and humidity.
  • Data logging system records parameters every 60 seconds.
  • Intuitive HMI with individual user logins and levels.
  • Glove and leak testing.
  • Sterile liquid transfer ports.
  • Equipment integration with power sockets.
  • Event Log capturing all user, event and alarm records ensuring data integrity.
  • External EMS and sensor connections.
  • Data Logging with Ethernet download to servers.
  • Remote ethernet access.
  • Full URS, FAT, SAT, IQ/OQ, RQ validation packages.
  • 'Standby' feature (Eco mode) automatically decreases fan speed when the chamber is at rest to optimise energy efficiency.
  • Continuous viable and non-viable particle monitoring.
  • Active air sampling.
  • Fully automated dehumidification system.
  • Bespoke trolley with cleanroom castors
  • Other optional features are available to tailor the system to your requirements.

Aspirate biological liquid waste from inside the chamber without compromising Grade A conditions with our Vacuum Take-off Port and Whitley AsPROvac.

View Specification


Capacity (litres)
Airlock Capacity
10 x 500ml Duran bottles in each airlock
Airlock Size (litres)
Porthole System
Gas Supplies
CO2, N2, Air
Internal Mains Sockets
Inspection Lamp
Data Logging
Airlock Cycle Time (seconds)
1 to 5 minutes
Extra Cable Glands
Automatic Dehumidifier
Removable Front
Trolley Available
CO2 Monitoring
Vacuum Take Off
O2 Profiling
Touchscreen Control
Remote Access
As Standard
Dimensions (W/D/H mm)
2940 / 1130 / 1080
Weight (lbs/kgs)
1298 / 590
Whitley H135 GMP Isolator

For a smaller GMP Hypoxystation, see the single chamber H135 ...

Whitley H135 GMP Isolator

Choose a Country

If you are based in Germany or Australia, please select the website of our subsidiary company there. A different selection of products is available in these countries. Otherwise, please select ‘English’ and you will be able to find your local distributor in the ‘Overseas Distributors’ section.

Share this

Please select your preferred language from the list below


Don't have an account? Click Here

Forgot your password? Click Here